CELLvo Matrix

The only cell-derived matrix that mimics the native niche in vitro. Get better results with CELLvo™.

Naturally derived 3D matrix for healthy, robust more physiological relevant cell culture studies. The next evolution in stem cell research.

  • StemBiosys Cellvo matrices

    Key Features

    • CELLvo™ Matrix overcomes key obstacles to isolating and expanding clinically useful stem cell for research, diagnostic and therapeutic applications
    • This cell-free culture substrate provides a native three-dimensional microenvironment which can be used for isolation and rapid expansion of various cell types.
    • The only commercially available substrate that aims to recapitulate biochemical as well as structural and mechanical cues of the native niche by leaving the extracellular matrix intact.
    • The best cell culture environment for growing primary cells Healthier and robust cell growth. Cells adhere and grow naturally which means that they retain their phenotype.
    • Optically clear substrate Unobstructed investigation by optical microscopy

CELLvo™Matrix 

Is an extracellular matrix (ECM) of proteins synthesized and constructed by bone marrow stromal cells. This product is composed of more than 150 proteins that were secreted and assembled by bone marrow cells during the production of the CELLvo™ Matrix. The final product is cell-free with only the ECM attached to the surface of the culture vessel. This cell culture substrate provides a native three-dimensional microenvironment which can be used for isolation and rapid expansion of various cell types.  For further information about the cells types, please visit CELLvo™Cells page on our AXT website.

CELLvo™ Matrix is the only commercially available substrate that aims to recapitulate biochemical as well as structural and mechanical cues of the native niche by leaving the extracellular matrix intact. Cell-derived matrices create a biologically-relevant culture environment for a variety of cell types by providing all the cues cells expect to receive in vivo in our culture dishes. This means that instead of responding to foreign culture conditions, cells respond to the customers’ experimental variables.

  • Cells used to produce CELLvo™Matrix are purchased from Lonza. The starting material, human bone marrow mononuclear cells, are procured from young, healthy individuals. The donors are screened for HIV and HepB.

Available products:

In addition to CELLvo™Matrix you can also find CELLvo™Xeno-free Matrix.

CELLvo™ XF Matrix

CELLvo™ XF Matrix is composed of more than 150 proteins that were secreted and assembled by the bone marrow cells during the production of the matrix. The CELLvo™ XF Matrix is produced xeno free allowing easy transition to translational studies. This cell culture substrate provides a native three-dimensional microenvironment which can be used for rapid and reliable cell expansion of high quality Mesenchymal Stem Cells (MSCs) and other adherent cells.

CELLvo™ Matrix Plus

CELLvo™ Matrix Plus is an extension of the CELLvo™ Matrix line that is produced by human stem cells. This ECM has been shown to enhance the isolation, growth and differentiation of a variety of different cell types including induced pluripotent stem cells (iPSCs). Consistent with all other CELLvo™ Matrix products, CELLvo™ Matrix Plus is easy to use requiring only a brief rehydration step prior to use.

CELLvo™ Matrix Plus comes in 6WP, T75, T150 and 96 WP.

CELLvo™ Matrix has been used to:

  • Expand various types of MSCs (bone marrow, adipose, umbilical cord blood, umbilical cord tissue, amniotic fluid)
  • Support maintenance of human Islet cells
  • Evaluate effects on various types of cancer cells
  • Support germ cells (oocytes) in culture
  • To stimulate bone healing
  • In general, we recommend the research product for use with any hard to grow cell

  • Learn about the production and use of the CELLvo Matrix

    The CELLvo Matrix is an Extracellular Matrix of proteins synthesized in vitro by bone marrow stromal cells. The product is composed of more than 150 proteins that were secreted and assembled by bone marrow cells during the production of CELLvo Matrix. The following animation describes this process in greater detail. The final product is cell-free with only the ECM attached to the surface of the dish. This cell culture substrate provides a native three -dimensional microenvironment, which can be used for rapid expansion of high quality mesenchymal stem cells.

  • StemBioSys Webinar – Cell Derived – The Next Evolution in Stem Cell Culture Matrices

    In this mini-webinar and accompanying article, Sy Griffey, PhD. Chief Operating Officer, StemBioSys, discusses cell-derived extracellular matrices as the next evolution in stem cell culture.

  • Advantages of CELLvo extracellular-matrix

    A unique video compares motility of culturing stem cells on tissue culture-treated plastic with CELLvo extracellular matrix. Visit www.stembiosys.com for more information.

  • All
  • Biological Microscopy
  • Cell Culture
  • Confocal Microscopy
  • Digital Microscopy
  • DNA/RNA
  • Extrustion Bioprinters
  • Fluorescent Microscopy
  • Light Microscopy
  • Live Cell Imaging
  • Microscopy
  • Molecular Biology
  • Optical Tweezers
  • Protein
  • Quantitative Phase Imaging
  • Small Molecule
  • Super Resolution Microscopy
  • Tomographic Microscopy

  • Schematic of the production method for CELLvo™ Matrices.

  • Heat map of gene expression of cells after seeding onto TCP vs. CELLvo™ Matrix.

  • ENABLES XENO-FREE ISOLATION: ______________________________ With CELLvo™ XF Matrix, cells naturally home and adhere to their new niche. With a variety of cell types, we routinely see more rapid attachment and proliferation of primary cells. (BM-MSC isolation from primary bone marrow mononuclear cells (100x) at day 14)